Controlled clinical trial of L-dopa and nafoxidine in advanced breast cancer: an E.O.R.T.C. study.

نویسندگان

  • E Engelsman
  • J C Heuson
  • J Blonk Van Der Wijst
  • A Drochmans
  • H Maass
  • F Cheix
  • L G Sobrinho
  • H Nowakowski
چکیده

L-Dopa lowers plasma prolactin levels, and there have been reports that patients with advanced breast cancer have been successfully treated with L-dopa. To test the potential value of L-dopa in this disease a randomized clinical trial of L-dopa and nafoxidine (as the reference compound) was conducted in postmenopausal women with advanced breast cancer. Objective remissions were obtained in sever out of 36 patients (19%) treated with nafoxidine but in none out of 40 patients treated with L-dopa. L-Dopa in the dose schedule used seems to be ineffective in advanced breast cancer.

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عنوان ژورنال:
  • British medical journal

دوره 2 5973  شماره 

صفحات  -

تاریخ انتشار 1975